Designer benzodiazepines and pregabalin A lethal combination

Presented By: Nigel Brown Speaker Biography: Nigel started work in 1982 as a Biomedical Scientist in the NHS and progressed by a circuitous route to the Institute of Psychiatry (King's College, London) where he worked as a Research Assistant and gained his PhD. A move back to the NHS followed were he worked in a laboratory measuring immunosuppressive drugs (initially by immunoassay, then by LC-MS/MS) for the liver transplant service at King's College Hospital. In 2011 he moved back to the North East of England to run the toxicology service at Wansbeck Hospital, which provides a referral service to NHS hospitals in the NE and N Cumbria, including a 24/7 service for ethylene glycol, routine drug screening for local drug recovery services, and post mortem toxicology for a number of Coroners in the region. He obtained his fellowship of the Royal College of Pathologists in 2014 (in Analytical Toxicology) and has recently just finished his term chairing the Toxicology Specialist Advisory Panel for Toxicology in the RCPath. In addition he is a deputy examiner (in Clinical Chemistry) for the Institute of Biomedical Science and has research interests in alcohol markers, particularly in pregnancy, with the long term goal of screening for infants at risk of developing FASD. Webinar: Designer benzodiazepines and pregabalin. A lethal combination Webinar Abstract: This talk will start with an introduction to a number of illicit benzodiazepines that have appeared in North East England over the last couple of years. This will be followed by an overview of the GABA-A receptor and its possible central role in the toxic effects of a number of CNS depressant drugs. Attention will move to pregabalin (and gabapentin) and their toxicity, which is becoming more apparent as time progresses. This will include some details of their receptor in the CNS and their modulatory effects on other CNS transmitter systems. I will also include some details of the detection method (using HRMS and LC-MS/MS) and planned improvements for this year. Earn PACE Credits: 1. Make sure you're a registered member of LabRoots https://www.labroots.com/ 2. Watch the webinar on the LabRoots Website https://www.labroots.com/webinar/designer-benzodiazepines-pregabalin-lethal-combination 3. Click Here to get your PACE credits (0505/2023): https://www.labroots.com/credit/pace-credits/5699 LabRoots on Social: Facebook: https://www.facebook.com/LabRootsInc Twitter: https://twitter.com/LabRoots LinkedIn: https://www.linkedin.com/company/labroots Instagram: https://www.instagram.com/labrootsinc Pinterest: https://www.pinterest.com/labroots/ SnapChat: labroots_inc

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